Advances in Mutagenesis Research by Günter Obe, H.H. Evans, D. Frankenberg, M.

By Günter Obe, H.H. Evans, D. Frankenberg, M. Frankenberg-Schwager, E. Gebhart, W. Köhnlein, R.H. Nussbaum, D.G. Papworth, J.R.K. Savage, R.-D. Wegner

Applied genetic study, genetic toxicology and mutation learn examine the mutagenicity and cancerogenicity of chemical substances and different brokers. everlasting mutation in genes and chromosomes, should be caused through a plethora of brokers, together with ionizing and nonionizing radiations, chemical compounds, and viruses. one of the elements mentioned via Advances in Mutagenesis Research are (1) the certainty of the molecular mechanisms resulting in mutations, and (2) the prevention of a inconsiderate creation of mutagenic brokers into the environment.

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GK loss refers to a decrease in galactokinase activity in homogenates of the TK'/' mutants to a value less than 80% of homogenates of the original TK+/' strains. Strain LY-RI6 and strain LY-SI are TK+/' heterozygotes; s~ain LY-SI is deficient in the repair of radiation- induced DNA double-strand breaks (Evans et al. 1987; Wlodek and Hittelman 1987). H. Evans Little 1989b). DNA lesions at the hprt locus of human TK6 cells were induced by 1251-iododeoxyuridine incorpbration into DNA: A greater percentage of HPRT mutants induced by the densely ionizing 1251 radiation showed hprt allele loss and rearrangement than after low-LET irradiation, but very few of the HPRT mutants showed lesions extending to neighboring genes whether induced by r125 or X-irradiation (Whaley and Little 1990).

2 Energy Deposition by Alpha Particles . . . . . . . . . . . . . . . 3 Evidence That Irreparable Lesions Are Induced by Alpha Particles . . . . . . . 4 Induction of DNA Double-Strand Breaks by Alpha Radiation . . . . . . . . . 5 Chromosomal Damage Induced by Alpha Radiation . . . . . . . . . . . 6 Mutagenicity of Alpha Radiation . . . . . . . . . . . . . . . . . 7 Characterization of Mutational Lesions Induced by Alpha Radiation .

Stud Biophys 88:87-96 Kampf G, Eichhorn K (1983) DNA strand breakage by different radiation qualities and relations to cell killing: Further results after the influence of a-particles and carbon ions. Stud Biophys 93: 17-26 Luchnik AN, Glaser VM, Shestakov SV (1977) Repair of DNA double-strand breaks requires two homologous DNA duplexes. Mol BioI Rep 3:437-442 Martin-Bertram H, Hagen U (1979) Genomic integrity ofTI DNA aftery- and UV irradiation. Biochim Biophys Acta 561:312-323 Natarajan AT, Obe G (1984) Molecular mechanisms involved in the production of chromosomal aberrations.

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